4',5,7-Trihydroxyisoflavone

27licensed products
1 monograph
Capsule, Capsule, hard, Tablet +2

Health Canada Monographs

1
SOYBEAN EXTRACTS AND ISOLATES
Oral

Approved Health Claims

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  • Helps to attenuate/reduce/decrease bone (mineral density (BMD)) loss in postmenopausal women when used in conjunction with adequate amounts of calcium and vitamin D
  • May reduce severe and frequent menopausal symptoms (such as hot flashes and/or night sweats)

Approved Dose Ranges

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PopulationDose RangeFrequency
Perimenopausal women; Postmenopausal women (D'Anna et al. 2007; Nahas et al. 2007; Crisafulli et al. 2004; Albert et al. 2002; Faure et al. 2002; Han et al. 2002; Scambia et al. 2000; Upmalis et al. 2000; Albertazzi et al. 1998).75–125 milligramsper day
Perimenopausal women; Postmenopausal women (D'Anna et al. 2007; Nahas et al. 2007; Crisafulli et al. 2004; Albert et al. 2002; Faure et al. 2002; Han et al. 2002; Scambia et al. 2000; Upmalis et al. 2000; Albertazzi et al. 1998).30–125 milligramsper day
Perimenopausal women; Postmenopausal women (D'Anna et al. 2007; Nahas et al. 2007; Crisafulli et al. 2004; Albert et al. 2002; Faure et al. 2002; Han et al. 2002; Scambia et al. 2000; Upmalis et al. 2000; Albertazzi et al. 1998).15–125 milligramsper day

Cautions & Contraindications

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cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you are not up-to-date on mammograms and gynaecological evaluations (Tomar and Shiao 2008; BfR 2007; Duffy et al. 2007; Palacios et al. 2007; Unfer et al. 2004; Petrakis et al. 1996).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician if symptoms worsen.
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you are taking blood thinners or any hormone replacement therapy (Rios et al. 2008; BfR 2007; Messina and Redmond 2006; ASHP 2005; Izzo et al. 2005; Mills and Bone 2005; Franco et al. 2004; Mazer 2004; Murray et al. 2003; Cambria-Keily 2002; Bell and Ovalle 2001; IOM 2001; Hansten et al. 1997; Petrakis et al. 1996).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you have a liver disorder or a history of hormonal or gynaecological disease (NIH 2022; Cecchi et al. 2009; Chandrareddy et al. 2008; Gasteyger et al. 2008; Tomar and Shiao 2008; Jefferson et al. 2007; Palacios et al. 2007; Kaari et al. 2006; Noel et al. 2006; Maskarinec et al. 2004a; Maskarinec et al. 2004b; Unfer et al. 2004; Borghi-Scoazec et al. 2002; Wu et al. 2000; Duncan et al. 1999b; Hargreaves et al. 1999; McMichael-Phillips et al. 1998; Petrakis et al. 1996).
contraindicationDo not use if you have or had breast cancer or tumours or a predisposition to breast cancer, as indicated by an abnormal mammogram or biopsy, or a family member with breast cancer (Helferich et al. 2008; Tomar and Shiao 2008; BfR 2007; Duffy et al. 2007; Kaari et al. 2006; Nikander et al. 2005; Hargreaves et al. 1999; McMichael-Phillips et al. 1998; Petrakis et al. 1996).
adverse_reactionStop use and ask a health care practitioner/health care provider/health care professional/doctor/physician if new symptoms develops such as breast pain, a recurrence of menstruation, uterine spotting or liver-related symptoms (e.g. abdominal pain, jaundice, dark urine) (Chandrareddy et al. 2008; Martinez and Lewi 2008; Palacios et al. 2007; Olawaiye et al. 2005; Albert et al. 2002; Han et al. 2002; Hargreaves et al. 1999; McMichael-Phillips et al. 1998; Petrakis et al. 1996).

Alternative Names

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7-O-beta-D-Glucopyranoside(common)Black soya bean(common)Da dou(common)Genistein(common)Genistein 7-glucoside(common)Genistin(common)Soy(common)Soy isoflavone extract(common)Soy protein concentrate(common)Soy protein isolate(common)Soya(common)Soyabean(common)Soybean(common)4',5,7-Trihydroxyisoflavone5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one7-(beta-D-glucopyranosyloxy)-3-(4- hydroxyphenyl)-4H-1-Benzopyran-4-oneGlycine maxSoy isoflavone extractSoy protein concentrateSoy protein isolate 1

Common Quantities in Licensed Products

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15 mg AIE14 licensed products
20 mg AIE6 licensed products
1.5 mg4 licensed products
16.7 mg AIE4 licensed products
30 mg AIE4 licensed products
50 mg4 licensed products
15 mg3 licensed products
20 AIE3 licensed products
0.389 AIE2 licensed products
13.5 mg AIE2 licensed products

Related Ingredients

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Soy protein isolateShared monographSoy isoflavone extractShared monographGenisteinShared monographSoy protein concentrateShared monograph5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneShared monograph7-(beta-D-glucopyranosyloxy)-3-(4- hydroxyphenyl)-4H-1-Benzopyran-4-oneShared monograph7-O-beta-D-GlucopyranosideShared monographBlack soya beanShared monograph

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