3,3'-Methylenebis-1H-indole

45licensed products
1 monograph
Capsule, Powder, Liquid +1

Health Canada Monographs

1

Approved Health Claims

4
  • Source of (an) antioxidant(s)/Provides (an) antioxidant(s)
  • Source of (an) antioxidant(s)/Provides (an) antioxidant(s) that help(s) fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals
  • Helps to support/promote healthy estrogen metabolism/balance
  • Helps reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia)

Approved Dose Ranges

1
PopulationDose RangeFrequency
Adults 18 years and older60–200 milligramsper day

Cautions & Contraindications

8
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use to exclude the diagnosis of a serious cause of hormonal imbalance (UpToDate 2024).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician if symptoms persist or worsen.
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you are taking medications or natural health products (Linus Pauling Institute 2017; Brinker 2010; Reed et al. 2005; Bradlow et al. 1994).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you are attempting to conceive (Bennetts et al. 2008; Michnovicz et al. 1997).
cautionStop use and ask a health care practitioner/health care provider/health care professional/doctor/physician if you develop liver-related symptoms (e.g., yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen (Reed et al. 2005; Dalessandri et al. 2004; Bell et al. 2000; Michnovicz et al. 1997; Wong et al. 1997; Bradlow et al. 1994).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations (Reed et al. 2005; Dalessandri et al. 2004; Bell et al. 2000; Michnovicz et al. 1997; Wong et al. 1997; Bradlow et al. 1994).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes or changes in libido (Reed et al. 2005; Dalessandri et al. 2004; Bell et al. 2000; Michnovicz et al. 1997; Wong et al. 1997; Bradlow et al. 1994).
contraindicationDo not use if you are pregnant or breastfeeding (Reed et al. 2006; Michnovicz et al.1997).

Alternative Names

4
3,3'-Diindolylmethane(common)DIM(common)3,3'-Diindolylmethane3,3'-Methylenebis-1H-indole

Common Quantities in Licensed Products

10
100 mg14 licensed products
4.16 milligrams8 licensed products
50 mg6 licensed products
25 mg5 licensed products
25 milligrams4 licensed products
70.8 Microgram4 licensed products
31.25 mg3 licensed products
150 mg3 licensed products
4.16 mg2 licensed products
6.25 mg2 licensed products

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