3,3'-Diindolylmethane (DIM)

Monograph
272products
single · Oral

Accepted Names (English)

4
3,3'-Diindolylmethane(common)DIM(common)3,3'-Diindolylmethane(proper)3,3'-Methylenebis-1H-indole(proper)

Accepted Names (French)

4
3,3'-Diindolylmethane(common)DIM(common)3,3'-Diindolylmethane(proper)3,3'-Methylenebis-1H-indole(proper)

Approved Health Claims

4
  • Source of (an) antioxidant(s)/Provides (an) antioxidant(s)
  • Source of (an) antioxidant(s)/Provides (an) antioxidant(s) that help(s) fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals
  • Helps to support/promote healthy estrogen metabolism/balance
  • Helps reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia)

Approved Health Claims (Français)

4
  • Source of (an) antioxidant(s)/Provides (an) antioxidant(s)
  • Source of (an) antioxidant(s)/Provides (an) antioxidant(s) that help(s) fight/protect (cell) against/reduce (the oxidative effect of/the oxidative damage caused by/cell damage caused by) free radicals
  • Helps to support/promote healthy estrogen metabolism/balance
  • Helps reduce the severity and duration of symptoms associated with recurrent breast pain (cyclical mastalgia)

Approved Dose Ranges

1
PopulationDose RangeFrequency
Adults 18 years and older60–200 milligramsper day

Cautions & Contraindications

8
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use to exclude the diagnosis of a serious cause of hormonal imbalance (UpToDate 2024).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician if symptoms persist or worsen.
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you are taking medications or natural health products (Linus Pauling Institute 2017; Brinker 2010; Reed et al. 2005; Bradlow et al. 1994).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you are attempting to conceive (Bennetts et al. 2008; Michnovicz et al. 1997).
cautionStop use and ask a health care practitioner/health care provider/health care professional/doctor/physician if you develop liver-related symptoms (e.g., yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen (Reed et al. 2005; Dalessandri et al. 2004; Bell et al. 2000; Michnovicz et al. 1997; Wong et al. 1997; Bradlow et al. 1994).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations (Reed et al. 2005; Dalessandri et al. 2004; Bell et al. 2000; Michnovicz et al. 1997; Wong et al. 1997; Bradlow et al. 1994).
cautionAsk a health care practitioner/health care provider/health care professional/doctor/physician before use if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes or changes in libido (Reed et al. 2005; Dalessandri et al. 2004; Bell et al. 2000; Michnovicz et al. 1997; Wong et al. 1997; Bradlow et al. 1994).
contraindicationDo not use if you are pregnant or breastfeeding (Reed et al. 2006; Michnovicz et al.1997).

Ingredients Covered

4

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